by Guest » Thu May 29, 2008 8:41 am
[b]"A review of the cases reported in Germany and Switzerland, based on the information available so far, is instructive. Of 34 cases reported (including duplicate reports), 18 appear to be associated with the concomitant use of prescription medications, some of which are known or suspected to be hepatotoxic. In some instances, people consumed kava at higher doses than recommended by the Commission E (60–120 mg kavalactones per day)11; one report shows that the subject exceeded this dose by 400 percent. Experts point to other potentially confounding co-factors that raise questions about kava’s culpability. Whether some of these AERs were caused by the simultaneous use of conventional drugs, the interaction of kava and the conventional drugs, or simply the kava products used still remains to be determined. However, what has become increasingly clear is that many of the AERs are clouded by numerous confounding variables. A detailed assessment by a board-certified toxicologist/pharmacologist on behalf of AHPA was released mid-February (described below)."
"The letter was posted on the FDA website [url]http://www.fda.gov[/url], and generated inquiries from the media during the following days. Since FDA’s request was made, the agency has received 20 reports of possible hepatotoxicity associated with kava, per a CD-ROM released by FDA on March 22, although the validity of these reports have not been fully confirmed by FDA or a third party.23"
"Although kava is approved as a safe and effective nonprescription drug by the German Commission E, much of the kava sold in Germany also is prescribed, as many physicians consider it a safe and effective first-line remedy to treat symptoms associated with anxiety, a condition for which it is approved."[/b]
[b]"The validity of these cases had not yet been confirmed by FDA or any third party."[/b]
[b]"It is likely that kava will be approved on a prescription basis starting in July 2002."[/b]
[b]"The report concludes:
… kava when taken in appropriate doses for reasonable periods of time has no scientifically established potential for causing liver damage. However as with any pharmacologically active agent, there is always the possibility of drug interactions, preexisting disease conditions and idiosyncratic or hypersensitivity reactions, which can exacerbate the toxicity of such an agent. Increased surveillance or reports of adverse effects and judicious use of kava-derived products under the conditions recommended by the natural products industry would be a most prudent approach to confirm its safety and minimize any risk of liver damage. The medical community and the general public should be made aware that concomitant intake of prescription drugs associated with liver damage, excessive alcohol consumption and preexisting liver disease or hepatitis with compromised liver function are conditions which may preclude any kava consumption.30"[/b]
So Fenix's 30mg shouldnt be a problem then? Im confused....
[link=http://content.herbalgram.org/new-chapter/herbalgram/articleview.asp?a=2147&p=Yl]Resource provided by Westfall[/link]